GLYBURIDE MICRONIZED ORAL (GLYNASE) BOXED WARNING: RISK OF THYROID C-CELL TUMORS See full prescribing information for complete boxed warning. • Liraglutide causes thyroid C-cell tumors at clinically relevant exposures in rodents. It is unknown whether Victoza causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as human relevance could not be determined by clinical or nonclinical studies. • Victoza is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). BEFORE USING THIS MEDICINE: Tell your doctor if you are having any of the following conditions: TOP KIDNEY DISEASE; LIVER PROBLEMS. * Inform your Doctor or Pharmacist if you are allergic to any prescription or non-prescription medicine; taking other medicines or have other medical problems; pregnant, planning a pregnancy, or breastfeeding. * Check with your Doctor, Pharmacists, or Nurse if information in this leaflet causes you special concern or if you want additional information about your medicine and its use. HOW MEDICINE IS ADMINISTERED? TOP Use this medicine exactly as directed on the label, unless instructed differently by your doctor * Take medication at the same time each day. * Take this medicine WITH food, a meal, or a snack. Do not take on an empty stomach. * Patients must receive full and complete instructions about the nature of DIABETES and learn to self-monitor blood glucose. * A reduced-calorie DIET and increased physical activity are usually part of the treatment regimen. Follow prescribed diet and exercise programs. * Use this medicine for the full prescribed treatment period. WARNINGS/PRECAUTIONS: TOP * There are no adequate or well-controlled safety studies in pregnant women. NOTIFY YOUR DOCTOR IF PREGNANT or intend to become pregnant. * Strict adherence to personal hygiene, avoidance of infection & foot care are essential. See your dentist twice a year & an ophthalmologist regularly. * Self-monitor blood glucose. Test urine for glucose and ketones as prescribed. Have glycosylated hemoglobin tested regularly. * Notify your doctor if signs of HYPERGLYCEMIA develops [eg, excessive thirst or urination, positive test for glucose or ketones in urine]. * Treat mild episodes of HYPOGLYCEMIA (weakness, nervousness, confusion, headache, nausea, dizziness, rapid respiration) with oral glucose. * Treat severe episodes of HYPOGLYCEMIA (coma, seizure or neurologic impairment) with glucagon IM/SC injection or concentrated IV glucose. * Notify your doctor if signs of INFECTION develops (eg, fever, sore throat, chills, or unusual bruising or bleeding). * Patients should wear identification tags (Medic-Alert) to alert medical personnel, in case of an emergency, to your condition or drugs you're taking. * Because of INTERACTIONS, report the use of any other prescription or nonprescription medicines, including natural/herbal remedies, to your doctor. * DO NOT DRINK alcoholic beverages or take alcohol-containing preparations while being treated with this medicine. * This medicine may cause increased sensitivity to the sun. You should AVOID prolonged or excessive exposure to direct and/or artificial sunlight. Stop taking this medicine and notify your doctor AS SOON AS POSSIBLE if you experience: Itching; Skin rash; Low blood sugar level. Other Common Side Effects: TOP Nausea; Headache; Heartburn; Gas; Stomach discomfort or pain; Vomiting; Increased sensitivity to sunlight; Diarrhea; Drowsiness; Dizziness. Other Common Side Effects: If symptoms are mild but do not go away or are bothersome, check with your doctor. IF ANY OF THE ABOVE SIDE EFFECTS IS SEVERE, CALL YOUR DOCTOR IMMEDIATELY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. This leaflet has been developed by CliniDATA Source, Inc. based primarily on labeling information provided by the manufacturer. The information does not cover all possible uses, actions, precautions, side effects, or interactions of this medicine. It is not intended as medical advice for individual patients. Copyright © CliniDATA Source, Inc. 09/10. All rights reserved